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Scientific studies

The company has worked towards rigour and science since its beginnings, conducting numerous studies to prove the safety and effectiveness of the Protein Diet vs. a low-calorie diet. More than 15 studies have been conducted to date, half of which have been published and presented in scientific forums.

Our main scientific studies are:

  • PnKLipoinflammation Study: A clinical trial by the Research Support Unit at the Río Hortega University Hospital in Valladolid. The main aim is to study the solution to chronic inflammation associated with obesity in patients on a weight-loss programme (PnK® Method).
  • ProKal Study: Clinical trial performed at the Obesity Unit at Gregorio Marañón General University Hospital in Madrid. The primary aim is to assess differences in weight loss between obese patients following the PronoKal® Method and those following a low-calorie diet.
    ProKal Study 12 months
    ProKal Study 24 months
  • DiaproKal® Study: Clinical study to assess the safety of a Protein Diet vs. a low-calorie diet for weight loss in obese patients with type 2 diabetes or prediabetes. This study was presented at the World Diabetes Congress held in Dubai in 2011, as well as in other venues. DiaproKal Study
  • Promesa I and II Studies: The purpose of these studies is to assess the safety and effectiveness of the PronoKal® Method for weight loss in overweight and obese patients.
  • Mexican adults study: Comparison between a standard low-calorie diet and the PronoKal® Method, based on the Protein Diet, in Mexican adults.
  • Systems biology and nutrition: Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate, low-fat ketogenic diet. This study was published in the journal "Nutrition&Metabolism" and explains why the ketosis achieved using the PronoKal® Method may work in patients with type 2 diabetes.
  • Diana Study: This study is being used to prepare a detailed description (demographic characteristics, concomitant diseases, habits, etc.) of the profile of overweight and diabetic patients being treated with the Protein Diet.
  • Proce-D Study: The aim of this study is to establish the typical capillary ketonemia values for diabetic or pre-diabetic patients undergoing weight loss treatment with the Protein Diet.
  • Promet Study: An international prospective registry of patients undergoing weight loss treatment with the Protein Diet (PronoKal® Method). The weight loss and evolution of factors related to being overweight are assessed as part of the PronoKal® Method.

Links of interest

PronoKal® Method Website DiaproKal® Method Website PronoKal Group® Foundation

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